Inferring 3D human motion is fundamental in many applications, including understanding human activity and analyzing one's intention. While many fruitful efforts have been made to human motion prediction, most approaches focus on pose-driven prediction and inferring human motion in isolation from the contextual environment, thus leaving the body location movement in the scene behind. However, real-world human movements are goal-directed and highly influenced by the spatial layout of their surrounding scenes. In this paper, instead of planning future human motion in a 'dark' room, we propose a Multi-Condition Latent Diffusion network (MCLD) that reformulates the human motion prediction task as a multi-condition joint inference problem based on the given historical 3D body motion and the current 3D scene contexts. Specifically, instead of directly modeling joint distribution over the raw motion sequences, MCLD performs a conditional diffusion process within the latent embedding space, characterizing the cross-modal mapping from the past body movement and current scene context condition embeddings to the future human motion embedding. Extensive experiments on large-scale human motion prediction datasets demonstrate that our MCLD achieves significant improvements over the state-of-the-art methods on both realistic and diverse predictions.
Federated Learning (FL) has emerged as a fundamental learning paradigm to harness massive data scattered at geo-distributed edge devices in a privacy-preserving way. Given the heterogeneous deployment of edge devices, however, their data are usually Non-IID, introducing significant challenges to FL including degraded training accuracy, intensive communication costs, and high computing complexity. Towards that, traditional approaches typically utilize adaptive mechanisms, which may suffer from scalability issues, increased computational overhead, and limited adaptability to diverse edge environments. To address that, this paper instead leverages the observation that the computation offloading involves inherent functionalities such as node matching and service correlation to achieve data reshaping and proposes Federated learning based on computing Offloading (FlocOff) framework, to address data heterogeneity and resource-constrained challenges. Specifically, FlocOff formulates the FL process with Non-IID data in edge scenarios and derives rigorous analysis on the impact of imbalanced data distribution. Based on this, FlocOff decouples the optimization in two steps, namely : (1) Minimizes the Kullback-Leibler (KL) divergence via Computation Offloading scheduling (MKL-CO); (2) Minimizes the Communication Cost through Resource Allocation (MCC-RA). Extensive experimental results demonstrate that the proposed FlocOff effectively improves model convergence and accuracy by 14.3\%-32.7\% while reducing data heterogeneity under various data distributions.
The advancement of artificial intelligence (AI) for organ segmentation and tumor detection is propelled by the growing availability of computed tomography (CT) datasets with detailed, per-voxel annotations. However, these AI models often struggle with flexibility for partially annotated datasets and extensibility for new classes due to limitations in the one-hot encoding, architectural design, and learning scheme. To overcome these limitations, we propose a universal, extensible framework enabling a single model, termed Universal Model, to deal with multiple public datasets and adapt to new classes (e.g., organs/tumors). Firstly, we introduce a novel language-driven parameter generator that leverages language embeddings from large language models, enriching semantic encoding compared with one-hot encoding. Secondly, the conventional output layers are replaced with lightweight, class-specific heads, allowing Universal Model to simultaneously segment 25 organs and six types of tumors and ease the addition of new classes. We train our Universal Model on 3,410 CT volumes assembled from 14 publicly available datasets and then test it on 6,173 CT volumes from four external datasets. Universal Model achieves first place on six CT tasks in the Medical Segmentation Decathlon (MSD) public leaderboard and leading performance on the Beyond The Cranial Vault (BTCV) dataset. In summary, Universal Model exhibits remarkable computational efficiency (6x faster than other dataset-specific models), demonstrates strong generalization across different hospitals, transfers well to numerous downstream tasks, and more importantly, facilitates the extensibility to new classes while alleviating the catastrophic forgetting of previously learned classes. Codes, models, and datasets are available at https://github.com/ljwztc/CLIP-Driven-Universal-Model
Text-based Person Retrieval (TPR) aims to retrieve person images that match the description given a text query. The performance improvement of the TPR model relies on high-quality data for supervised training. However, it is difficult to construct a large-scale, high-quality TPR dataset due to expensive annotation and privacy protection. Recently, Large Language Models (LLMs) have approached or even surpassed human performance on many NLP tasks, creating the possibility to expand high-quality TPR datasets. This paper proposes an LLM-based Data Augmentation (LLM-DA) method for TPR. LLM-DA uses LLMs to rewrite the text in the current TPR dataset, achieving high-quality expansion of the dataset concisely and efficiently. These rewritten texts are able to increase the diversity of vocabulary and sentence structure while retaining the original key concepts and semantic information. In order to alleviate the hallucinations of LLMs, LLM-DA introduces a Text Faithfulness Filter (TFF) to filter out unfaithful rewritten text. To balance the contributions of original text and augmented text, a Balanced Sampling Strategy (BSS) is proposed to control the proportion of original text and augmented text used for training. LLM-DA is a plug-and-play method that can be easily integrated into various TPR models. Comprehensive experiments on three TPR benchmarks show that LLM-DA can improve the retrieval performance of current TPR models.
Purpose: 4D MRI with high spatiotemporal resolution is desired for image-guided liver radiotherapy. Acquiring densely sampling k-space data is time-consuming. Accelerated acquisition with sparse samples is desirable but often causes degraded image quality or long reconstruction time. We propose the Reconstruct Paired Conditional Generative Adversarial Network (Re-Con-GAN) to shorten the 4D MRI reconstruction time while maintaining the reconstruction quality. Methods: Patients who underwent free-breathing liver 4D MRI were included in the study. Fully- and retrospectively under-sampled data at 3, 6 and 10 times (3x, 6x and 10x) were first reconstructed using the nuFFT algorithm. Re-Con-GAN then trained input and output in pairs. Three types of networks, ResNet9, UNet and reconstruction swin transformer, were explored as generators. PatchGAN was selected as the discriminator. Re-Con-GAN processed the data (3D+t) as temporal slices (2D+t). A total of 48 patients with 12332 temporal slices were split into training (37 patients with 10721 slices) and test (11 patients with 1611 slices). Results: Re-Con-GAN consistently achieved comparable/better PSNR, SSIM, and RMSE scores compared to CS/UNet models. The inference time of Re-Con-GAN, UNet and CS are 0.15s, 0.16s, and 120s. The GTV detection task showed that Re-Con-GAN and CS, compared to UNet, better improved the dice score (3x Re-Con-GAN 80.98%; 3x CS 80.74%; 3x UNet 79.88%) of unprocessed under-sampled images (3x 69.61%). Conclusion: A generative network with adversarial training is proposed with promising and efficient reconstruction results demonstrated on an in-house dataset. The rapid and qualitative reconstruction of 4D liver MR has the potential to facilitate online adaptive MR-guided radiotherapy for liver cancer.
Enzymes are genetically encoded biocatalysts capable of accelerating chemical reactions. How can we automatically design functional enzymes? In this paper, we propose EnzyGen, an approach to learn a unified model to design enzymes across all functional families. Our key idea is to generate an enzyme's amino acid sequence and their three-dimensional (3D) coordinates based on functionally important sites and substrates corresponding to a desired catalytic function. These sites are automatically mined from enzyme databases. EnzyGen consists of a novel interleaving network of attention and neighborhood equivariant layers, which captures both long-range correlation in an entire protein sequence and local influence from nearest amino acids in 3D space. To learn the generative model, we devise a joint training objective, including a sequence generation loss, a position prediction loss and an enzyme-substrate interaction loss. We further construct EnzyBench, a dataset with 3157 enzyme families, covering all available enzymes within the protein data bank (PDB). Experimental results show that our EnzyGen consistently achieves the best performance across all 323 testing families, surpassing the best baseline by 10.79% in terms of substrate binding affinity. These findings demonstrate EnzyGen's superior capability in designing well-folded and effective enzymes binding to specific substrates with high affinities.
The recent introduction of prompt tuning based on pre-trained vision-language models has dramatically improved the performance of multi-label image classification. However, some existing strategies that have been explored still have drawbacks, i.e., either exploiting massive labeled visual data at a high cost or using text data only for text prompt tuning and thus failing to learn the diversity of visual knowledge. Hence, the application scenarios of these methods are limited. In this paper, we propose a pseudo-visual prompt~(PVP) module for implicit visual prompt tuning to address this problem. Specifically, we first learn the pseudo-visual prompt for each category, mining diverse visual knowledge by the well-aligned space of pre-trained vision-language models. Then, a co-learning strategy with a dual-adapter module is designed to transfer visual knowledge from pseudo-visual prompt to text prompt, enhancing their visual representation abilities. Experimental results on VOC2007, MS-COCO, and NUSWIDE datasets demonstrate that our method can surpass state-of-the-art~(SOTA) methods across various settings for multi-label image classification tasks. The code is available at https://github.com/njustkmg/PVP.
Open-set Semi-supervised Learning (OSSL) holds a realistic setting that unlabeled data may come from classes unseen in the labeled set, i.e., out-of-distribution (OOD) data, which could cause performance degradation in conventional SSL models. To handle this issue, except for the traditional in-distribution (ID) classifier, some existing OSSL approaches employ an extra OOD detection module to avoid the potential negative impact of the OOD data. Nevertheless, these approaches typically employ the entire set of open-set data during their training process, which may contain data unfriendly to the OSSL task that can negatively influence the model performance. This inspires us to develop a robust open-set data selection strategy for OSSL. Through a theoretical understanding from the perspective of learning theory, we propose Wise Open-set Semi-supervised Learning (WiseOpen), a generic OSSL framework that selectively leverages the open-set data for training the model. By applying a gradient-variance-based selection mechanism, WiseOpen exploits a friendly subset instead of the whole open-set dataset to enhance the model's capability of ID classification. Moreover, to reduce the computational expense, we also propose two practical variants of WiseOpen by adopting low-frequency update and loss-based selection respectively. Extensive experiments demonstrate the effectiveness of WiseOpen in comparison with the state-of-the-art.
Graph self-supervised learning has sparked a research surge in training informative representations without accessing any labeled data. However, our understanding of graph self-supervised learning remains limited, and the inherent relationships between various self-supervised tasks are still unexplored. Our paper aims to provide a fresh understanding of graph self-supervised learning based on task correlations. Specifically, we evaluate the performance of the representations trained by one specific task on other tasks and define correlation values to quantify task correlations. Through this process, we unveil the task correlations between various self-supervised tasks and can measure their expressive capabilities, which are closely related to downstream performance. By analyzing the correlation values between tasks across various datasets, we reveal the complexity of task correlations and the limitations of existing multi-task learning methods. To obtain more capable representations, we propose Graph Task Correlation Modeling (GraphTCM) to illustrate the task correlations and utilize it to enhance graph self-supervised training. The experimental results indicate that our method significantly outperforms existing methods across various downstream tasks.
This paper delves into the task of arbitrary modality salient object detection (AM SOD), aiming to detect salient objects from arbitrary modalities, eg RGB images, RGB-D images, and RGB-D-T images. A novel modality-adaptive Transformer (MAT) will be proposed to investigate two fundamental challenges of AM SOD, ie more diverse modality discrepancies caused by varying modality types that need to be processed, and dynamic fusion design caused by an uncertain number of modalities present in the inputs of multimodal fusion strategy. Specifically, inspired by prompt learning's ability of aligning the distributions of pre-trained models to the characteristic of downstream tasks by learning some prompts, MAT will first present a modality-adaptive feature extractor (MAFE) to tackle the diverse modality discrepancies by introducing a modality prompt for each modality. In the training stage, a new modality translation contractive (MTC) loss will be further designed to assist MAFE in learning those modality-distinguishable modality prompts. Accordingly, in the testing stage, MAFE can employ those learned modality prompts to adaptively adjust its feature space according to the characteristics of the input modalities, thus being able to extract discriminative unimodal features. Then, MAFE will present a channel-wise and spatial-wise fusion hybrid (CSFH) strategy to meet the demand for dynamic fusion. For that, CSFH dedicates a channel-wise dynamic fusion module (CDFM) and a novel spatial-wise dynamic fusion module (SDFM) to fuse the unimodal features from varying numbers of modalities and meanwhile effectively capture cross-modal complementary semantic and detail information, respectively. Moreover, CSFH will carefully align CDFM and SDFM to different levels of unimodal features based on their characteristics for more effective complementary information exploitation.